Diffuse neurofibrillary tangles with calcification in a non-demented woman.

Diffuse neurofibrillary tangles with calcification: a new presenile dementia.

The term "diffuse neurofibrillary tangles with calcification" (DNTC) is proposed for a new form of presenile dementia. It is characterised by slowly progressive cortical dementia in the presenium, localised temporal or temporofrontal lobar atrophy, numerous neurofibrillary tangles widespread in the cerebral cortex, and pronounced calcareous deposits; 16 cases of DNTC, have been reported.

Challenging the concept of diffuse neurofibrillary tangles with calcification (Kosaka-Shibayama disease).

Masaya Mukai and Keigo Shibayama

Are routine methods good enough to stain senile plaques and neurofibrillary tangles in different brain regions of demented patients?

INTRODUCTION Numerous clinical cases have been reported showing the clinical picture of dementia but not meeting the neuropathological criteria for Alzheimer's dementia (AD). Different methods used to stain senile plaques (SPs) and neurofibrillary tangles (NFTs) might account for this discrepancy. SUBJECTS AND METHODS Here, brains of 11 patients with dementia were examined. Cryosections and p...

Senile plaques and neurofibrillary tangles in cortical neurons in AD

Neurodegenerative disorders are characterized clinically by insidious onset and slowly progressive course, and are frequently hereditary. Pathologically, these diseases share a common feature: the selective loss of a particular subset of neurons for unknown reasons [e.g. cerebral cortical neurons in ALZHEIMER’S DISEASE (AD) (see Glossary), substantia nigra neurons in PARKINSON’S DISEASE (PD), s...